Chinese Journal of Medical Genetics http://zhyxycx.life/index.php/cjmg <p>"Journal of Medical Genetics," formerly known as "genetic disease" in 1992 changed its name to "Journal of Medical Genetics." Purpose of the magazine are: reflecting China's medical genetics, human genetics, genomics and human disease, the theory and technology related fields the latest research results, implementing the theory and practice, popularization and improvement of the policy; main audience is engaged in medical the work of clinical genetics doctors, family planning workers, teachers and tertiary students and researchers. With Commentary, of the technology and methods, review, report, clinical genetics, genetic counseling, clinical cytogenetics, case reports and other columns. Since 1998, the U.S. magazine "<strong>Medical Index</strong>" (Index Medicus, MEDLINE, PubMed), "<strong>Chemical Abstracts</strong>" (Chemical Abstract), "<strong>Engineering Index</strong>" (Engeering Index, Ei Compendex-CD, Ei CompendexWeb), "<strong>Biological Abstracts</strong> "(Biological Abstract), and the Netherlands," <strong>Medical Digest</strong> "(Excerpta Medica), and Russia," <strong>Digest Magazine</strong> "(Abstract Journal) of six renowned international retrieval systems <strong>Scopus, BIOSIS, EMBASE</strong>. China were Wanfang database, Chinese Academic Journal CD-ROM, CD-ROM Chinese Biomedical Literature Database, and "Chinese Science Abstracts", 15 abstracts included. Magazine won the 1995 and 2000, the first prize of Excellent journals; in 1995 and 2001 were excellent journal of the Chinese Medical Association Silver; 1997 and 2002, China Association for Science were awarded second prize and third prize of excellent journals.</p> <table style="height: 124px;" width="580"> <tbody> <tr> <td width="192"> <p><strong>Publication Type</strong></p> </td> <td> <p>Journal</p> </td> </tr> <tr> <td width="192"> <p><strong>Scope</strong></p> </td> <td> <p>Genetics (clinical) (Q4); Medicine (miscellaneous), BioEngineering, Pharmacology and pharmacy (Q4)</p> </td> </tr> <tr> <td width="192"> <p><strong>Access</strong></p> </td> <td> <p>Subscription Required</p> </td> </tr> <tr> <td width="192"> <p><strong>Frequency </strong></p> </td> <td> <p>Bio-Monthly</p> </td> </tr> <tr> <td width="192"> <p><strong>Publisher</strong></p> </td> <td> <p>West China University of Medical Sciences</p> </td> </tr> </tbody> </table> <p>The <strong>impact score</strong> (IS) 2020 of <strong class="w3-text-black">Chinese Journal of Medical Genetics </strong>is<strong class="w3-text-black"> 0.13</strong>, which is computed in 2021 as per its definition. <strong class="w3-text-black">Chinese Journal of Medical Genetics </strong>IS is <strong>decreased</strong> by a factor of <strong>0.07</strong> and approximate percentage change is <strong>-35%</strong> when compared to preceding year 2019, which shows a <strong>falling</strong> trend. The impact score (IS), also denoted as Journal impact score (JIS), of an academic journal is a measure of the yearly average number of citations to recent articles published in that journal. It is based on Scopus data.</p> <p>The IS0 4 standard abbreviation of <strong>Chinese Journal of Medical Genetics</strong> is <strong>Chin. J. Med. Genet.</strong>. This abbreviation ('Chin. J. Med. Genet.') is well recommended and approved for the purpose of indexing, abstraction, referencing and citing goals. It meets all the essential criteria of ISO 4 standard.</p> <p>ISO 4 (International Organization for Standardization 4) is an international standard that defines a uniform and consistent system for abbreviating serial publication titles and journals.</p> West China University of Medical Sciences en-US Chinese Journal of Medical Genetics 1003-9406 EXERCISES ACCORDING TO THE PRESSURE APPLIED TO THE FEET AND THE LENGTH OF THE STEP AND THEIR IMPACT ON REDUCING THE DIFFERENCES IN THE DISTANCE OF THE STEP BEFORE THE BARRIER FOR THE TEN HURDLES AND ACHIEVING THE EFFECTIVENESS OF RUNNING (110 M) HURDLES http://zhyxycx.life/index.php/cjmg/article/view/482 <p>The aim is to prepare exercises for the applied pressure and the length of the step and to find out their effect on the completion and reduction of the differences in the distance before the barrier on the runner of the event of running (110) meters hurdles, as well as knowing the size of the impact of the exercises on the distance before the barrier, the moment of passing the ten barriers and completion before and after applying the exercises.To achieve this goal, the researcher used the experimental approach with a one-person design (A-) (A-B) with multiple attempts, in order to suit the nature of the research problem. Since the nature of the research requires several attempts, six attempts were applied to form a database.Then the researcher worked to determine the research variables, which were represented by (the distance before the barrier at the moment of crossing, the effective completion of 110-meter hurdles(In order to extract the step length of each barrier, the researcher used video imaging as one of the means of analysis through which movement can be studied and described. Note . The 110-meter hurdles run was filmed using (10) iPhone pro devices. They are placed to the right of each of the ten hurdles, at a distance of (4) meters, and at a height of (110) cm from the ground. Then he started applying the pre-tests in the Samawah Olympic Stadium, as the player was tested with 6 attempts within three days, with two attempts every day, and then he started applying the exercises prepared for the player for a period of (12) weeks, with (3) training units per week. Thus, the total number of units for the exercises is (36) units using the repetitive training method, with an intensity ranging from (90-100)%, as the exercises were carried out during the days (Sunday - Tuesday - Thursday) of each week, using the wave (1:1) between weeks and (1). 2) between training units. After completing the application of the vocabulary of the prepared curriculum, the researcher proceeded to apply the post-tests, and after obtaining the results, the researcher used the statistical program (SSPSv27.1) to obtain the results. The barrier between the ten hurdles, which led to regular running speed over a distance of 110 meters hurdles, and this was reflected positively in improving the time of completion by effectively running (110) meters hurdles.</p> Ahmed Ali Sadiq*, Prof. Dr. Ayad Abed Rahman Alshammery & Prof. Dr. Hayder Balash Jwbur Copyright (c) 2023 2023-08-15 2023-08-15 32 3 1 13 THE EFFECT OF COMPLEX EXERCISES USING SMART GLASSES IN DEVELOPING THE SPEED OF MOTOR RESPONSE AND THE SKILL OF HOLDING HIGH BALLS FOR ADVANCED SOCCER GOALKEEPERS http://zhyxycx.life/index.php/cjmg/article/view/483 <p>The study aimed to prepare complex training exercises using smart glasses to develop the speed of motor response and the skill of holding high balls for advanced soccer goalkeepers, and to identify its impact on the research variables. While the study hypothesized that there is a positive effect of compound exercises using smart glasses on the speed of motor response and the skill of catching high balls for advanced soccer goalkeepers, and in favor of post-tests, while theoretical studies included compound exercises using smart glasses and their impact on developing the speed of motor response and the skill of catching high balls for goalkeepers. The advanced football goal, and the researcher followed the experimental method in the manner of three groups, two experimental groups, and a control group, due to its suitability to the nature and objectives of the research.</p> Haidar Nafel Rassin Alanzy* & Prof. Dr Habeeb Shakir Jebur Copyright (c) 2023 2023-08-15 2023-08-15 32 3 14 23 THE EFFECT OF SELF-KINETIC EXERCISES IN DEVELOPING THE SKILL OF PREPARING VOLLEYBALL FOR VOLLEYBALL PLAYERS http://zhyxycx.life/index.php/cjmg/article/view/484 <p>The current research aims to prepare self-kinetic exercises and apply them to the players of Al-Rumaitha Club in volleyball and to know the effect of exercises in developing the skill of preparing for volleyball. To achieve this goal, the researcher used the experimental approach by designing the two equal groups, as it is more appropriate to the nature of the research problem. As for the research community, it was represented by the volleyball players of Al-Rumaitha Club, who numbered (12) players for the sports season (2022-2033 AD), as they were randomly divided into two control and experimental groups, with (6) players for each group. After that, the researcher proceeded to apply the tribal research tests on the research sample, and after collecting the results, he divided the research sample into two groups and made sure of their homogeneity and equivalence, and then proceeded to apply the psychomotor exercises on the experimental research sample for a period of 8 weeks, at 3 units per week, and after completing the application Psychomotor exercises proceed with post-tests. After collecting the data, the researcher used the statistical program (SPSS v27) for the purpose of analyzing the results, and accordingly, the researcher concluded that the psychomotor exercises prepared by the researcher have a role in developing the skill of preparing for volleyball, and this was shown by the results, as the experimental group that applied the kinesthetic exercises outperformed the control group that applied the trainer's exercises.</p> Mohammed Naqi Taki* & Prof. Dr. Oras Neama Hassa Copyright (c) 2023 2023-08-15 2023-08-15 32 3 23 32 EXERCISES ACCORDING TO THE PRESSURE APPLIED TO THE FEET AND THE LENGTH OF THE STEP AND THEIR IMPACT ON REDUCING THE DIFFERENCES IN THE STEP OF PASSING THE TEN HURDLES AND ACHIEVING THE EFFECTIVENESS OF RUNNING (110 M) HURDLES http://zhyxycx.life/index.php/cjmg/article/view/485 <p>The aim is to prepare exercises for applying pressure and the length of the step and knowing its effect on the runner of the 110m hurdles event, as well as knowing the size of the impact of the Hijaz step difference at the moment of crossing the ten hurdles and completing it before and after applying the exercises.To achieve this goal, the researcher used the experimental approach with a one-person design (A-) (A-B) with multiple attempts, in order to suit the nature of the research problem. Since the nature of the research requires several attempts, six attempts were applied to form a database.Then the researcher worked to determine the search variables, which were represented by (the step of passing each barrier, the effective achievement of 110 meters hurdles( In order to extract the step length of each barrier, the researcher used video imaging as one of the means of analysis through which movement can be studied and described. Note . The 110-meter hurdles run was filmed using (10) iPhone pro devices. They are placed to the right of each of the ten hurdles, at a distance of (4) meters, and at a height of (110) cm from the ground. Then he started applying the pre-tests in the Samawah Olympic Stadium, as the player was tested with 6 attempts within three days, with two attempts every day, and then he started applying the exercises prepared for the player for a period of (12) weeks, with (3) training units per week. Thus, the total number of units for the exercises is (36) units using the repetitive training method, with an intensity ranging from (90-100)%, as the exercises were carried out during the days (Sunday - Tuesday - Thursday) of each week, using the wave (1:1) between weeks and (1). 2) between training units. After completing the application of the vocabulary of the prepared curriculum, the researcher proceeded to apply the post-tests, and after obtaining the results, the researcher used the statistical program (SSPSv27.1) to obtain the results, so the researcher concluded that the pressure exercises and the length of the step prepared by the researcher contributed to reducing the differences in the passing step. Among the ten hurdles, which led to regular running speed over a distance of 110m hurdles, and this was reflected positively in improving the time of completion by effectively running (110m) hurdles.</p> Ahmed Ali Sadiq*, Prof. Dr. Ayad Abed Rahman Alshammery & Prof. Dr. Hayder Balash Jwbur Copyright (c) 2023 2023-08-15 2023-08-15 32 3 33 45 THE EFFECT OF SELF-KINETIC EXERCISES IN DEVELOPING THE SKILL OF RECEIVING SERVE IN VOLLEYBALL FOR VOLLEYBALL PLAYERS http://zhyxycx.life/index.php/cjmg/article/view/486 <p>The current research aims to prepare self-kinetic exercises and apply them to the players of Al-Rumaitha Club in volleyball and to know the effect of exercises in developing the skill of receiving the serve in volleyball.To achieve this goal, the researcher used the experimental approach by designing the two equal groups, as it is more appropriate to the nature of the research problem.As for the research community, it was represented by the volleyball players of Al-Rumaitha Club, who numbered (12) players for the sports season (2022-2033 AD), as they were randomly divided into two control and experimental groups, with (6) players for each group.After that, the researcher proceeded to apply the tribal research tests on the research sample, and after collecting the results, he divided the research sample into two groups and made sure of their homogeneity and equivalence, and then proceeded to apply the psychomotor exercises on the experimental research sample for a period of 8 weeks, at 3 units per week, and after completing the application Psychomotor exercises proceed with post-tests.After collecting the data, the researcher used the statistical program (SPSS v27) for the purpose of analyzing the results, and accordingly, the researcher concluded that the psychomotor exercises prepared by the researcher have a role in developing the skill of receiving the serve in volleyball, and this was shown by the results, as the experimental group that applied the kinesthetic exercises excelled the control group that applied the trainer's exercises.</p> Mohammed Naqi Taki* & Prof. Dr. Oras Neama Hassan Copyright (c) 2023 2023-08-15 2023-08-15 32 3 46 54 THE EFFECT OF OVERLAPPING WAVES STRATEGY ON LEARNING THE FOREHAND TENNIS SKILL FOR STUDENTS http://zhyxycx.life/index.php/cjmg/article/view/487 <p>One of the most prominent features of the current era is the tremendous development in quantity and quality and the scientific acceleration of human knowledge and its continuous renewal. This requires changing our view of science and teaching so that we work to educate young people to be able to take responsibility and develop and advance their society.Teaching strategies are means of thinking and analysis used by those in charge of the teaching process to facilitate the learner's task in understanding the educational tasks, as it is an interactive process between the teacher, the learner, and the subject. It relates to all aspects that facilitate the learning process, such as teaching methods and methods of stimulating learners' motivation and employing them in a manner that takes into account the learners' tendencies, desires, and aptitudes. This is based on the selection and use of available means and capabilities in the teaching process to achieve the desired goals.</p> <p>It seems that interest in the teaching process has prompted those interested in the educational process to think about devising strategies that take into account all the data of the situation that will be dealt with, and since the overlapping of learning aspects with thinking is an important factor through which the initial specific information is provided with mental stimulation to expand the knowledge wave, then it becomes smaller and then expanded.</p> Wisam Shakir Rzaej* & Prof. Dr. Mohammed Muter Araak Copyright (c) 2023 2023-08-15 2023-08-15 32 3 65 74 PEDAGOGICAL CONTENT KNOWLEDGE (PCK) AND ITS IMPACT ON THE SCIENTIFIC KNOWLEDGE OF SCIENTIFIC RESEARCH FOR MASTER'S STUDENTS IN SOME FACULTIES OF PHYSICAL EDUCATION AND SPORTS SCIENCES http://zhyxycx.life/index.php/cjmg/article/view/488 <p>The current research aims to build a measure of educational content knowledge ((PCK), and to prepare a measure of scientific knowledge of scientific research methods and to apply these three measures to master's students in some faculties of physical education and sports sciences to identify the level of these standards among students, as well as to identify the correlations between the two measures.To achieve the objectives of the research, the researcher used the descriptive approach in the two methods (survey – correlation(As for the research community, it was represented by graduate students (Masters) at the stage of writing the research, from (9) faculties of physical education and sports sciences for the academic year (2020-2021) and (2021-2022). Their number is (370) students, with a rate of (216). Students from the first academic year and (154) students from the second academic year. As for the research sample, the researcher determined her research sample randomly from the students of the selected colleges, whose number is (270) students, by (160) students from the first academic year to represent the sample of building standards, and (110) students of the second academic year to represent the sample of the main experiment, then the researcher built educational content knowledge (PCK) consisting of (13) items, and the researcher also prepared a measure of scientific knowledge for scientific research methods, as the researcher used the scale prepared for the researcher (Akram Adnan Naghimish It consists of (44) items in a multiple choice format with three alternatives (a, b, c). Then the researcher applied the three measures to master's students from (8) faculties of physical education and sports sciences, and after obtaining the results, the researcher used the statistical program (SPSS) to analyze the data and show the results.Accordingly, the researcher concluded that the educational content knowledge (PCK) has an impact on the scientific knowledge of scientific research methods for master's students.</p> Hanaa Wali Dubai* & Prof. Dr. Asaad Tareq Ahmed Copyright (c) 2023 2023-08-15 2023-08-15 32 3 75 85 CONTENT KNOWLEDGE (CK) AND ITS RELATIONSHIP TO SCIENTIFIC KNOWLEDGE IN SCIENTIFIC RESEARCH FOR MASTER'S STUDENTS IN SOME FACULTIES OF PHYSICAL EDUCATION AND SPORTS SCIENCES http://zhyxycx.life/index.php/cjmg/article/view/489 <p>The current research aims to build a measure of content knowledge (CK), and to prepare a measure of scientific knowledge of scientific research methods and to apply these three measures to master's students in some faculties of physical education and sports sciences to identify the level of these standards among students, as well as to identify the correlations between the two measures.To achieve the objectives of the research, the researcher used the descriptive approach in the two methods (survey – correlation(As for the research community, it was represented by graduate students (Masters) at the stage of writing the research, from (9) faculties of physical education and sports sciences for the academic year (2020-2021) and (2021-2022). Their number is (370) students, with a rate of (216). Students from the first academic year and (154) students from the second academic year. As for the research sample, the researcher determined her research sample randomly from the students of the selected colleges, whose number is (270) students, by (160) students from the first academic year to represent the sample of building standards, and (110) students of the second academic year to represent the sample of the main experiment, then the researcher built content knowledge (CK) consisting of (12) items, and the researcher also prepared a measure of scientific knowledge for scientific research methods, as the researcher used the scale prepared for the researcher (Akram Adnan Naghimish) It consists of (44) items in the form of multiple choice with three alternatives (a, b, c). Then the researcher applied the three measures to master's students from (8) faculties of physical education and sports sciences, and after obtaining the results, the researcher used the statistical program (SPSS) to analyze the data and show the results. Accordingly, the researcher concluded that content knowledge (CK) has a correlation with scientific knowledge in scientific research methods for master's students.</p> Hanaa Wali Dubai* & Prof. Dr. Asaad Tareq Ahmed Copyright (c) 2023 2023-08-15 2023-08-15 32 3 88 100 ANAEROBIC EXERCISE IN COMBINATION WITH THE SUPPLEMENT (N.O.XPLODE) AND THEIR EFFECT ON (CPK) ENZYME CONCENTRATIONS AND LACTIC ACID FOR WHEELCHAIR PLAYERS http://zhyxycx.life/index.php/cjmg/article/view/490 <p>The progress made in various fields of life has opened a door to science and knowledge, and countries have been racing with each other to reach the highest levels of sophistication and progress and to benefit from the experiences of others and add something new to the field of human knowledge, and the sports field is one of the pillars of this development and derived its importance from the integration of proper nutrition And his life program, taking care of his body, and integrating every movement that a person makes with mental processes aimed at the activity practiced, as physical abilities can be of great value by using some modern nutritional supplements that lead to healthy integration and balance of physical effort, so the use of different and appropriate methods for the athlete to improve the level And performance has an impact on sports and it has an applied value and a special relationship for those concerned with the development of sports performance through the learner's tendency to choose the style that suits him, which leads positively to improving the level of performance in order to achieve the correct motor performance and master the skill better with all activity and dynamism. The importance of the research lies in the benefit that accrues to raising the level of productivity or efficiency of performance for tennis players, which is important in improving the level of performance, and thus reaching an integrated player needed by the wheelchair tennis game, which depends on the effectiveness in order to serve the development of this game to achieve the best results in local and international competitions The use of methods and a tight sports system through training and good nutrition and according to the type of training and following different methods in dealing with sports problems is in itself an art in shortening the way to reach the results and the desired level easily and effectively.</p> Salam Hussein Shakir*, Prof. Dr. Aqeel Moslem Abdul Hussein & Assistant Prof. Dr. Khalid Oudah Gshayyish Copyright (c) 2023 2023-08-15 2023-08-15 32 3 101 111 PERIOPERATIVE ANAESTHETIC MANAGEMENT OF PATIENT WITH APLASTIC ANAEMIA POSTED FOR EMERGENCY LAPAROTOMY: CASE REPORT http://zhyxycx.life/index.php/cjmg/article/view/491 <p>Aplastic anaemia is rare and serious blood condition in which there is failure of pluripotent stem cell system which is characterised by pancytopenia and bone marrow hypoplasia. Surgical and anaesthetic challenges in aplastic anaemia occurs secondary to anaemia, thrombocytopenia, immunosuppressive therapy and blood transfusion reactions. Here we describe successful perioperative anaesthetic management of adult patient with aplastic anaemia posted for emergency laparotomy in view of perforation peritonitis.</p> Dr Madhu*, Dr Binny Sachdeva, Dr Asha, Dr Roopa & Dr Himadri Chanda Copyright (c) 2023 2023-08-15 2023-08-15 32 3 112 114 EVALUATING ROOT CANAL CONFIGURATION OF PERMANENT MANDIBULAR INCISORS USING CBCT IN AN IRAQI SUBPOPULATION (MIDDLE EUPHRATES REGION) http://zhyxycx.life/index.php/cjmg/article/view/494 <p>Background/purpose: The purpose of this study was to determine the morphology of root canal space of permanent mandibular incisors in a sample of population of Karbala governorate in Iraq using cone-beam computed tomography images.</p> <p>Materials and methods: A total of (263) CBCT images including (980) mandibular incisors were included in this study. Number of roots, root canals and root canal configuration according to Vertucci classification were evaluated and analyzed statistically. Gender prevalence of root canal configuration was also evaluated.</p> <p>Results: All the examined incisors had a single root. About 66.43% had single root canal, while two canals were found in 33.57% of the teeth. The differences between males and female and between central and lateral incisors were statistically insignificant (p &lt; 0.05). Vertucci canal configuration types I, II, III, and V were detected, type I was the most prevalent (66.43%) followed by type III (30.2%), then type II (3.27%), and type V was found in only one case (0.1%). There was high degree of bilateral symmetry regarding canal number (89.12%) for central incisors and (88.84%) for lateral incisors.</p> <p>Conclusion: In Karbala governorate, bouts 1/3 of mandibular incisors have two root canals with different configurations. These findings are comparable to those reported in Iraqi-Kurdistan region.</p> Ala Mahdi Muhamed Ali. MSc, Ali S. Al-Haddad . MSc, Sundus Mohammed Ali Al-Bazi. MSc, Rafid J. Al-Badr. MSc Copyright (c) 2023 2023-08-30 2023-08-30 32 3 115 121 PREVALENCE OF “HEPATITIS B & C” AMONG BLOOD DONOR (BD) AT A TERTIARY CARE CENTRE (TCC) BLOOD BANK: A CROSS-SECTIONAL STUDY http://zhyxycx.life/index.php/cjmg/article/view/495 <p>Safe blood donation, a procedural cornerstone, is imperative in medical emergencies. This intricate process orchestrates a meticulous choreography, spanning the nuanced overture of donor counselling to the decisive denouement of blood release. However, within this carefully composed symphony, the emergence of transfusion-transmitted maladies, notably hepatitis B and C, imparts a disconcerting note to the harmony. These infections' escalating seropositivity during pre-storage screening injects an element of urgency into this narrative. Against this backdrop, our study unveils its exclusive goal: to illuminate the prevalence of ‘Hepatitis B virus (HBV) and Hepatitis C virus (HCV)’ within the select cast of BDs gracing the grand stage of a tertiary care centre's blood bank. The chronicle is scripted through a temporal window spanning from the inaugural month of January 2020 to the valedictory month of August 2023, firmly rooted in the geographical tapestry of Uttar Pradesh, India.</p> <p>A compelling dichotomy takes centre stage within this tableau, meticulously curated from the medical annals of 2404 robust donors. The virtuoso performance of replacement donors commands rapt attention, claiming a resounding 96% spotlight, while the understated ensemble of voluntary BDs humbly contributes a mere 4% to the chorus. The discernible reverberations of this contrast resound with statistical eminence (p &lt; 0.000485), painting a vivid tableau of significance. However, amid this symphonic choreography, a disquieting leitmotif unfurls. The prevalence of ‘hepatitis B and C’, once mere whispers within the score, crescendos into prominence in the annals of recent years. Their rising prevalence casts a contemplative shadow, an evocative reminder against complacency. As the study's final movement arrives, the crescendo recedes into a reflective coda. The evolving landscape of attitudes toward blood donation enriches the rural narrative, broadening the very canvas of the blood bank's domain. Nonetheless, this expansion is a double-edged sword, necessitating unwavering dedication to the vigilant overture of blood screening and the precautionary symphony. Only through this harmonious vigil can we hope to silence the discordant strains of transfusion-transmitted afflictions, thereby securing the rhythm of an era marked by safer blood transfusions.</p> Alka Upreti, Radhey Shyam Verma, Sanjeev Kumar Yadav*, Rinki Kumari Copyright (c) 2023 2023-08-30 2023-08-30 32 3 122 129 GENETICS RISK FACTORS FOR THE DEVELOPMENT OF CELIAC DISEASES AND TREATMENT APPROACH http://zhyxycx.life/index.php/cjmg/article/view/497 <p>Celiac disease is a complicated autoimmune condition were the immune system attack its own tissue when gluten was ingested with global prevalence in the general population is about 1%. A large genetic contribution to celiac disease susceptibility is estimated, ranging from 4 to 15% but, the inheritance pattern is unknown. The genetics of celiac disease have been intensively studied which have led the identification of a genetic liability to either human leukocyte antigen (HLA) DQ2 or DQ8 located on chromosome 6p21 in celiac disease patient .1</p> <p>Ingestion of gluten proteins promotes immune-mediated inflammation of the proximal small intestine along with villous atrophy in addition to crypt hyperplasia, leading to serious gastrointestinal and malabsorption conditions. Despite this, this disease is always misdiagnosed and there is lake in knowledge of proper treatments and medical interventions2.&nbsp; This review examines the main findings in genomic studies of celiac disease as well as the direction of the proper diagnosis and treatment approaches in order to further improve our knowledge of celiac disease genes Using the suspected patient’s genetic information will grant a better understanding of celiac disease pathogenesis also, will promote the developments toward a more precise diagnosis and treatment.</p> Rawan A. AL-Suhaimat Copyright (c) 2023 2023-09-14 2023-09-14 32 3 130 134 THE IMPACT OF MATERNAL IRON DEFICIENCY ANEMIA ON FETAL DEVELOPMENT, MATURATION, AND IRON LEVELS AMONG THE INDIAN POPULATION: INSIGHTS FROM A CLINICAL COHORT STUDY IN EASTERN UTTAR PRADESH http://zhyxycx.life/index.php/cjmg/article/view/498 <p>Background and Objective: Iron deficiency anaemia (IDA) remains a global public health challenge, particularly affecting pregnant women and their newborns in resource-constrained regions. This study aimed to investigate the impact of maternal iron status on neonatal outcomes in Eastern Uttar Pradesh, India, where IDA prevalence is high, intending to inform interventions for maternal and child health improvement.</p> <p>Methods: A clinical cohort study was conducted from December 2020 to February 2022 at Sir Sunder Lal Hospital in Varanasi, India. Based on haemoglobin and serum ferritin levels, 359 pregnant women were categorized into anaemic (Group I) and non-anaemic (Group II). Clinical assessments, laboratory investigations, and anthropometric measurements were conducted to assess maternal and neonatal iron status and other relevant parameters.</p> <p>Results: Group I (Anemic) exhibited lower haemoglobin, serum ferritin, and serum iron levels, along with higher TIBC levels compared to Group II (Non-Anemic). Anemic infants in Group I displayed lower haemoglobin, serum ferritin, and serum iron levels and higher TIBC levels compared to non-anaemic infants in Group II. Maternal folate and vitamin B12 levels were lower in Group I. Fetal growth parameters were compromised in anaemic mothers, with reduced fetal weight, Length, and head circumference. Positive -correlations were observed between maternal and infant haemoglobin and serum ferritin levels.</p> <p>Conclusion and Global Implementation: This study underscores the importance of addressing maternal iron deficiency during pregnancy to improve maternal and neonatal health. Interventions targeting maternal nutrition and iron supplementation should be prioritized, especially in resource-limited settings. These findings have global relevance, offering insights into the Significance of early detection and management of maternal iron deficiency to enhance maternal and child health worldwide, particularly in underserved regions with high IDA prevalence.</p> <p><strong>&nbsp;</strong></p> Anubha Bajpai, Rekha Devi, Alka Rai, Rinki Kumari, Dubey GP* Copyright (c) 2023 2023-09-18 2023-09-18 32 3 135 149