THE CORRELATION BETWEEN CHANGES IN D-DIMER AND CRP WITH SEVERITY AND MORTALITY IN COVID-19 PATIENTS
Keywords:Covid-19; D-Dimer; CRP; Severity; Kirkuk.
The SARS-CoV-2 outbreak occurred in Wuhan, China, close to the end of 2019. In weeks, a health crisis emerged, sickening millions of people. It has a major impact on the respiratory system, resulting in severe acute respiratory distress syndrome. This case-control study was carried out in Kirkuk general hospital (covid-19 epidemic and isolation center) from the period started from 1st of November 2020 to the end of January 2021, The study included 60 patients with positive rRT-PCR for Covid-19 admitted to hospital or treated as an outpatient. Patients classified into (20 patients with severe symptoms ,20 patients with moderate symptoms and 20 patients with mild symptoms) depending on clinical findings and SPO2 level, their Ages varied between 25-85 years. The study also included 30 healthy control individuals with negative rRT-PCR for Covid-19 and no apparent chronic diseases. Blood were collected from participants and laboratory investigation performed which includes (D-dimer, S fibrinogen and C-reactive protein). The study showed a significant increase in all measured laboratory parameters in patients with positive rRT-PCR when compared to control group with no apparent clinical disease. D-dimer showed an increase by a mean of (2.18 mcg/ml) when compared to control group (0.23 mcg/ml) with a p value of (<0.05). And when it’s level compared between the patient groups (severe, moderate and mild), it’s noted that it’s level mostly increased in the severe patient group with a mean of (4.61mcg/ml) when compared to the moderate and mild groups with a p value (<0.05). CRP increased in the patient group by a mean of (60.24 mg/l) when compared to the control group (2.39 mg/l) with a p value (<0.05). And likewise D-dimer, it’s mostly increased in the severe patient group by a mean of (86.27 mg/l) when compared to other groups, with a p value (<0.05).
As a conclusion to our research, these measures can be utilized as predictors for illness progression, intensity, or follow-up after therapy since higher levels of D-dimer, fibrinogen, and CRP were linked to a worse prognosis and death.