USING OF BAICALIN IN AMELIORATING LIVER AND KIDNEY FUNCTIONS IN ACRYLAMIDE TREATED RABBITS
Keywords:Baicalin, acrylamide, liver, kidney.
Objective: this study designed to discovery probability for using of baicalin to decrease toxic effects of acrylamide in functions of kidney and liver in female rabbits.
Methods: twenty adult female rabbits were used, about (11-12) month old, with average weight about (1100-1600) gm. The animals were distributed into four groups (5 animals per each) and drenched orally for 30 following days. Control group (C) drenched 1 ml of distilled water. T1 group drenched baicalin (50 mg/kg of body weight). T2 group drenched acrylamide (50 mg/kg of body weight). T3 group drenched both Baicalin and acrylamide at the same time. After the end of the treatment, the samples of blood were taken from the heart to obtain the serum for estimation of uric acid, Creatinine, ALT and AST.
Results: Our study revealed an important increased in uric acid, creatinine, ALT and AST levels at T2 group while these parameters decreased in T3 group.
Conclusion: Baicalin (50 mg/kg) plays a great role in reducing the side effect resulting from treatment with acrylamide in the liver and kidney functions in female rabbits.